Role of Gut Microbiota in Hepatocarcinogenesis

Role of Gut Microbiota in Colorectal Cancer

Colorectal cancer (CRC), an age-related malignancy whose incidence increases markedly after the age of 50 years, is the third most common cancer worldwide and shows significant variations in the distribution globally [1,2]. More than 1.2 million new cases of colorectal cancer (CRC) are reported each year, most of which (~85%) occur sporadically as a result of the accumulation of mutations and e...

Role of Gut Microbiota in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic autoimmune disease, caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental agent affecting the development of RA. Here we review the evidence from animal and human studies that supports the role of the gut microbiota in RA. We and others have demonstrated that t...

Gut Microbiota and Neuropsychiatric Disorders

Bugging inflammation: role of the gut microbiota

The advent of vaccination and improved hygiene have eliminated many of the deadly infectious pathogens in developed nations. However, the incidences of inflammatory diseases, such as inflammatory bowel disease, asthma, obesity and diabetes are increasing dramatically. Research in the recent decades revealed that it is indeed the lack of early childhood microbial exposure, increase use of antibi...

Impact of the Gut Microbiota on Vaccine Responses

Non-responsiveness or poor responsiveness to vaccines are challenging issues in vaccine development, and efforts have been made to find out the potential reasons for these conditions. Intestinal microbiome plays a key role in regulating and development of immune system and the composition and diversity of microbiota in different individuals on the one hand, and the imbalance of intestinal micro...